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Principle Investigators

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Prof. Dr. Michael Lalk
Head of the Evolutionary Genetics Group

Address Ernst-Moritz-Arndt-University Greifswald
Institute of Biochemistry
Felix-Hausdorff-Strasse 4
DE-17487 Greifswald
GERMANY
Phone +49-(0)-3834-86-4867
Fax +49-(0)-3834-86-4413
E-Mail lalk@uni-greifswald.de 
Web Ernst-Moritz-Arndt-University Greifswald

 

 

 

 

Short Biography

Prof. Dr. rer. nat. Michael Lalk 
Ernst Moritz Arndt University Greifswald, Institute of Biochemistry

Date of Birth: 09.07.1972

 

Scientific career

1991-1996: Study of Chemistry, University of Rostock, Germany

1996: Diploma in Chemistry

1996-1999: PhD work at the University of Rostock (Prof. Klaus Peseke),

1999: PhD (Dr. rer. nat.) in Organic Chemistry

1999-2000: Postdoc at the ETH Zurich, Switzerland (Prof. Andrea T. Vasella),

2000-2007: Habilitation work at the Institute of Pharmacy, University of Greifswald

2007: Habilitation (Dr. rer. nat. habil.)

2008: venia legendi for Bioorganic Chemistry, University of Greifswald

2008: Head of the research group „Metabolomics“ at the Department of Pharmaceutical Biology and the Competence-Center „ZIK-FunGene“ at the University of Greifswald

2012: Call for a W2-Professorship “Systems-Biology of Sepsis” at the Friedrich-Schiller University Jena (declined)

2012: Call for a W2-Professorship “Biochemistry” at the Ernst Moritz Arndt University Greifswald (accepted)

 

Current position

Professor for Biochemistry (Biochemistry of metabolism & Metabolomics)

 

Awards:

1991-1996 Stipendium der “Studienstiftung des Deutschen Volkes”

1996-1999 Promotionsstipendium der “Studienstiftung des Deutschen Volkes”

1999-2000 Forschungsstipendium der “Deutschen Forschungsgemeinschaft”

2000-2001 Liebig-Stipendium des “Fonds der Chemischen Industrie”

2004 SYNTHESIS-SYNLETT Journals Award

 

 

Recent publications relevant to Symbiomics

Prof. Dr. Lalk, Michael (Greifswald)

 

  1. Geiger, T., Francois, P., Liebeke, M., Fraunholz, M., Goerke, C., Krismer, B., Schrenzel, J., Lalk, M., Wolz, C. (2012) The Stringent Response of Staphylococcus aureus and its Impact on Survival after Phagocytosis Through the Induction of Intracellular PSMs Expression. PLOS Pathog 8: e1003016.
  2. Birkenstock, T., M. Liebeke, V. Winstel, B. Krismer, C. Gekeler, M. J. Niemiec, H. Bisswanger, M. Lalk and A. Peschel (2012) Exometabolome analysis identifies pyruvate dehydrogenase as a target for the antibiotic triphenylbismuthdichloride in multiresistant bacterial pathogens. J Biol Chem 287:2887-2895.
  3. Kleiner M, Wentrup C, Lott C, Teeling H, Wetzel S, Young J, Chang YJ, Shah M, Verberkmoes NC, Zarzycki J, Fuchs G, Markert S, Hempel K, Voigt B, Becher D, Liebeke M, Lalk M, Albrecht D, Hecker M, Schweder T, Dubilier N. (2012) Metaproteomics of a gutless marine worm and its symbiotic microbial community reveal unusual pathways for carbon and energy use. Proc. Natl. Acad. Sci. USA. 109, E1173-1182.
  4. Liebeke, M., K. Dörries, D. Zühlke, S. Fuchs, J. Bernhardt, J. Pane-Farre, S. Engelmann, R. Bode, T. Dandekar, U. Völker, U. Lindequist, M. Hecker and M. Lalk (2011) A Metabolomics and Proteomics study of the adaptation of Staphylococcus aureus to glucose starvation. Mol BioSyst 7:1241-1253.
  5. Otto, A., J. Bernhardt, H. Meyer, M. Schaffer, F. A. Herbst, J. Siebourg, U. Mäder, M. Lalk, M. Hecker and D. Becher (2010) Systems-wide temporal proteomic profiling in glucose-starved Bacillus subtilis. Nat Commun 1:137.
  6. Liebeke, M., H. Meyer, S. Donat, K. Ohlsen and M. Lalk (2010) A metabolomic view of Staphylococcus aureus and its Ser/Thr kinase and phosphatase deletion mutants: Involvement in cell wall biosynthesis. Chem Biol 17:820-830.
  7. Meyer, M., M. Liebeke and M. Lalk (2010) A protocol for the investigation of the intracellular Staphylococcus aureus metabolome. Anal Biochem 401: 250-259.
  8. Liebeke, M., Brözel, V.S., Hecker, M., Lalk, M. (2009) Chemical characterisation of soil extract as growth media for the ecophysiological study of bacteria. Appl Microbiol Biotech 83: 161-173.